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Real-world data published in JAMA confirmed that tirzepatide was associated with significantly greater weight loss than semaglutide in clinical practice, not just in controlled trial settings

Part D plans may consider using prior authorization for these products to ensure they are being used for a medically accepted indication, the CMS spokesperson added.

Reversibility: The oral medication has a shorter half-life than the injectable

Semaglutide is approved for chronic weight management in adults who meet specific BMI criteria, even without type 2 diabetes

Beyond its effects on glucose metabolism, semaglutide acts on receptors in the brain's appetite centers, particularly in the hypothalamus and brainstem

Insurance coverage is usually straightforward, and prior authorization approvals are more likely